Peptides for losing body fat and gaining muscle mass: sermorelin & ipamorelin

As we age, we lose muscle mass, gain fat, suffer insomnia, and recover slowly after exercise. One reason is the natural loss of growth hormone (GH). Naturally occurring growth hormone peaks during our adolescent years and continues to decline in our 30’s and 40’s. That’s one reason you aren’t sleeping, and despite exercising regularly and eating right, you still can’t lose that stubborn fat. Dieting leads to muscle loss, too. Sermorelin and ipamorelin helps normalize GH back to optimal range. Studies show sermorelin & ipamorelin burns fat and increases lean muscle mass by stimulating the production of GH in the pituitary gland.

People can build a tolerance to sermorelin and ipamorelin, therefore, it is dosed 5 out of 7 nights a week. This medication is a subcutaneous injection given at bedtime at least 90 minutes after your last caloric intake.

Sermorelin and ipamorelin are FDA approved for delayed physical development in children and GH deficiency. If you choose to take sermorelin or ipamorelin, understand that this is an off-label use and not approved by the FDA for weight loss.

What you may expect with Sermorelin or ipamorelin injections: in 3-4 days, deep sleep begins to improve. In 3-4 weeks, you may notice a quicker recovery following exercise and will have an improved sense of well-being. In 2.5-3 months, you will see a loss of body fat and increased muscle mass on the scale. I recommend logging your sleep, sense of well being and fat loss + muscle gains in a journal.

References:

Vitiello, M. V., Schwartz, R. S., Moe, K. E., Mazzoni, G., & Merriam, G. R. (2001). Treating age-related changes in somatotrophic hormones, sleep, and cognition. Dialogues in clinical neuroscience, 3(3), 229–236. https://doi.org/10.31887/DCNS.2001.3.3/mvvitiello

Sinha, D. K., Balasubramanian, A., Tatem, A. J., Rivera-Mirabal, J., Yu, J., Kovac, J., Pastuszak, A. W., & Lipshultz, L. I. (2020). Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Translational andrology and urology, 9(Suppl 2), S149–S159. https://doi.org/10.21037/tau.2019.11.30

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